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Fig. 6 | Microbial Cell Factories

Fig. 6

From: Development of an antibody-ligand fusion protein scFvCD16A-sc4-1BBL in Komagataella phaffii with stimulatory activity for Natural Killer cells

Fig. 6

scFvCD16A-sc4-1BBL enhanced the therapeutic effect of adoptively transferred NK cells in a xenograft model of human epithelial ovarian cancer (OC). a The schematic timeline of the establishment of a human OC solid tumor model with Ho-8910 in NCG mice and treatments. b Animal bioluminescence imaging was used to quantify the tumor burden of different combination treatment groups on the indicated days. One mouse from the NK + PBS group died accidently c Summary of bioluminescence measurements for different combination treatment groups. d The survival curves of mice in different combination treatment groups. Data are represented as the mean ± SD, n = 5 mice per group. Significant differences were determined by one-way ANOVA. * p < 0.05; ** p < 0.01; *** p < 0.001

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Microbial Cell Factories

ISSN: 1475-2859

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