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Fig. 2 | Microbial Cell Factories

Fig. 2

From: Improved biosynthesis of heme in Bacillus subtilis through metabolic engineering assisted fed-batch fermentation

Fig. 2

Growth curves, heme production, ALA production and gene transcriptional level of the recombinant strains constructed by engineering the endogenous C5 pathway. (A) Growth curves of wild-type B. subtilis 168, starting strain BS168N and recombinant strains BSH1, BSH2, BSH3, and BSH4. (B) Total heme production of B. subtilis 168, BS168N and recombinant strains after 36 h of fermentation. (C) Extracellular and intracellular ALA production of BSH1 and BSH2, total ALA production of BSH3 and BSH4 after 36 h of fermentation. (D) Transcriptional level of the hemA gene in BSH3, relative to that in BSH2, defined as 1

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