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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Improved biosynthesis of heme in Bacillus subtilis through metabolic engineering assisted fed-batch fermentation

Fig. 1

Schematic diagram of the heme biosynthetic pathway and overall engineering strategy in B. subtilis. GltA, glutamate synthase (large subunit); GltB, glutamate synthase (small subunit); GltX, glutamyl-tRNA synthetase; HemA, glutamyl-tRNA reductase; HemL, glutamate-1-semialdehyde aminotransferase; ALAS, 5-aminolevulinate synthase; HemB, porphobilinogen synthase; HemC, hydroxymethylbilane synthase; HemD, uroporphyrinogen (urogen) III synthase; HemE, urogen III decarboxylase; HemZ, coproporphyrinogen III oxidase; HemN, anaerobic coproporphyrinogen III oxidase; HemY, coproporphyrinogen oxidase; HemH, coproporphyrin ferrochelatase; HemQ, coproheme decarboxylase; CcmABC, heme exporter; RocG, glutamate dehydrogenase; GcvT, aminomethyltransferase (glycine cleavage system protein T); GcvPA, glycine decarboxylase subunit 1; GcvPB, glycine decarboxylase subunit 2; NasF, uroporphyrinogen methyltransferase; HmoA and HmoB, heme monooxygenase

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Microbial Cell Factories

ISSN: 1475-2859

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