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Fig. 3 | Microbial Cell Factories

Fig. 3

From: Improving the production of 9α-hydroxy-4-androstene-3,17-dione from phytosterols by 3-ketosteroid-Δ1-dehydrogenase deletions and multiple genetic modifications in Mycobacterium fortuitum

Fig. 3

Schematic of the genomic organization of kstD homologs in M. fortuitum ATCC 35855 and other mycobacteria. M.for, Mycobacterium fortuitum ATCC 35855; M.neo, M. neoaurum DSM 1381; M.tub, M. tuberculosis H37Rv, M.seg, M. smegmatis mc2155. The direction and size of genes are indicated as an arrow according to the scale at the bottom. Orthologous counterparts are included in light blue. KstD encodes putative 3-ketosteroid-Δ1-dehydrogenase; Ksh encodes putative terminal oxygenase of KSH; HsaE-G encodes putative hydratase, 4-hydroxy-2-oxovalerate aldolase, and aldehyde dehydrogenase; Relevant indicates other related enzymes involved in the steroid metabolism process

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