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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Improving the production of 9α-hydroxy-4-androstene-3,17-dione from phytosterols by 3-ketosteroid-Δ1-dehydrogenase deletions and multiple genetic modifications in Mycobacterium fortuitum

Fig. 1

Schematic diagram of phytosterol metabolism in Mycobacterium. The red arrow represents the C19-pathway, the blue arrow represents the C22 pathway, and the dotted lines represents uncertain responses. Chox Cholesterol oxidase, Hsd4A 17β‑hydroxysteroid dehydrogenase/β‑hydroxyacyl‑CoA dehydrogenase, FadA5 acetyl‑CoA acetyltransferase/thiolase, ChsEs acyl‑CoA dehydrogenases, KstD 3‑ketosteroid‑Δ1‑dehydrogenase, KSH 3‑ketosteroid‑9α‑hydroxylase, AD 4-androstene-3,17-dione, ADD 1,4-androstadiene-3,17-dione, 9-OHAD 9α-hydroxy-4-androsten-3,17-dione, 4-HP 21-hydroxy-20-methyl-pregna-4-en-3-one; HPD 21-hydroxy-20-methyl-pregna-1,4-diene-3-one, 9‑OHHP 9,21‑dihydroxy‑20‑methyl‑pregna‑4‑en‑3‑one, 3-OPC-CoA 3-oxo-4-pregnene-20-carboxyl-CoA. 3-OPA 3-oxo-4-pregnene-20-carboxyl aldehyde.

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Microbial Cell Factories

ISSN: 1475-2859

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