Membrane-based continuous fermentation with cell recycling for propionic acid production from glycerol by Acidipropionibacterium acidipropionici

Table 2 Comparison of propionic acid production parameters obtained in high-cell density systems of A. acidipropionici established by different means

Means for high-cell density	Mode of operation	Carbon source, g/L	Q_p, g/L.h	Y, g_P/g_S	Titer, g/L	References
Immobilization on polyethyleneimine coated Poraver beads	Batch	Glycerol, ~ 85 g/L	0.35	0.47	35.23	[25]
Immobilization on polyethyleneimine coated Poraver beads	Continuous	Glycerol, 30 g/L	1.44	0.69	14.38	[25]
Cell recycling	Sequential batch	Glycerol, ~ 50 g/L	1.42	0.63	27.3	[14]
Cell recycling	Sequential batch	Glycerol, 90 g/L	1.63	0.59	ca. 45	[26]
Recycling 10% of the culture	Cyclic batch	Glycerol, 90 g/L	0.53	0.75	42.5	[26]
Spin filter-assisted cell retention	Continuous	Lactose, 50 g/L	0.9	0.40	18.5	[46]
Spin filter-assisted cell retention	Continuous	Whey, 30–35 g/L lactose concentration	0.72	0.54	14.5	[60]
Spiral-membrane module	Semi-continuous	Glucose and glycerol, 100 g/L in total	0.43	-	62.22	[57]
Ultrafiltration module	Continuous	Whey, 25 g/L lactose concentration	2.14	0.43	7	[49]
Ultrafiltration module	Continuous	Glucose/xylose, 50 g/L in total	2.2	0.42	16.2	[19]
Membrane-assisted cell recycling	Continuous	Glycerol, 64.50 g/L	1.82	0.75	36.25	This work

ISSN: 1475-2859