Table 2 Ames test performed for SCB employing the histidine-requiring Salmonella typhimurium mutant TA98 and TA100 strains
From: Biological activity of new bioactive steroids deriving from biotransformation of cortisone
Salmonella typhimurium TA98 | Salmonella typhimurium TA100 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
− S9 | + S9 | − S9 | + S9 | |||||||||
average | SD | t/c | average | SD | t/c | average | SD | t/c | average | SD | t/c | |
DMSO | 24 | 4 | 1.0 | 32 | 4 | 1.0 | 166 | 10 | 1.0 | 191 | 15 | 1.0 |
C + | 1142 | 99 | 47.0 | 1302 | 59 | 40.0 | 1002 | 56 | 6.0 | 2477 | 110 | 13.0 |
1 | 24 | 5 | 1.0 | 34 | 4 | 1.1 | 157 | 9 | 0.9 | 190 | 9 | 1.0 |
5 | 23 | 5 | 0.9 | 35 | 3 | 1.1 | 169 | 11 | 1.0 | 194 | 10 | 1.0 |
10 | 22 | 4 | 0.9 | 35 | 5 | 1.1 | 164 | 7 | 1.0 | 193 | 12 | 1.0 |
50 | 21 | 5 | 0.9 | 31 | 5 | 1.0 | 169 | 11 | 1.0 | 189 | 9 | 1.0 |
100 | 19 | 2 | 0.8 | 30 | 5 | 0.9 | 180 | 11 | 1.1 | 195 | 8 | 1.0 |