Table 1 Ames test performed for SCA employing the histidine-requiring Salmonella typhimurium mutant TA98 and TA100 strains
From: Biological activity of new bioactive steroids deriving from biotransformation of cortisone
Salmonella typhimurium TA98 | Salmonella typhimurium TA100 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
− S9 | + S9 | − S9 | + S9 | |||||||||
average | SD | t/c | average | SD | t/c | average | SD | t/c | average | SD | t/c | |
DMSO | 20,7 | 5,1 | 1.0 | 37,3 | 3,2 | 1.0 | 165.7 | 6.8 | 1.0 | 181.0 | 7.0 | 1.0 |
C + | 1141,7 | 99,1 | 55.2 | 1302,0 | 59,2 | 34.9 | 1001.7 | 56.1 | 6.0 | 2477.3 | 110.0 | 13.7 |
1 | 17,7 | 5,5 | 0.9 | 43,7 | 5,9 | 1.2 | 163.0 | 8.5 | 1.0 | 179.3 | 15.2 | 1.0 |
5 | 23,7 | 2,1 | 1.1 | 43,3 | 3,8 | 1.2 | 164.3 | 6.1 | 1.0 | 181.7 | 9.6 | 1.0 |
10 | 23,3 | 2,5 | 1.1 | 41,3 | 3,5 | 1.1 | 158.0 | 5.0 | 1.0 | 185.3 | 14.7 | 1.0 |
50 | 25,3 | 4,5 | 1.2 | 39,3 | 2,9 | 1.1 | 157.0 | 7.0 | 0.9 | 205.7 | 10.5 | 1.1 |
100 | 20,3 | 2,1 | 1.0 | 41,3 | 2,9 | 1.1 | 166.7 | 5.0 | 1.0 | 194.3 | 8.0 | 1.1 |