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Scheme 1 | Microbial Cell Factories

Scheme 1

From: Origin of the 3-methylglutaryl moiety in caprazamycin biosynthesis

Scheme 1

Proposed biosynthesis model for the 3-methylglutaryl moiety in caprazamycin biosynthesis. In bold: Steps investigated in this study. BCDH: Branched-chain α-keto acid dehydrogenase complex. Sco2774: acyl-CoA dehydrogenase. Sco2779: isovaleryl-CoA dehydrogenase (LiuA). Sco2776: 3-methylcrotonyl-CoA carboxylase subunit β (LiuB). Sco2777: 3-methylcrotonyl-CoA carboxylase subunit α (LiuD). Sco2778: 3-hydroxy-3-methylglutaryl-CoA lyase (LiuE). Cpz5: 3-hydroxy-3-methylglutaryl-CoA synthase. Cpz20: acyl-CoA synthase. Cpz21: carboxylesterase. Cpz25: reductase

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