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Fig. 1 | Microbial Cell Factories

Fig. 1

From: High-yield production of protopanaxadiol from sugarcane molasses by metabolically engineered Saccharomyces cerevisiae

Fig. 1

Biosynthesis pathways for PPD production in metabolically engineered S. cerevisiae. Single arrows represent one-step enzymatic conversions, and triple arrows represent multiple steps. Arrows marked in blue represent overexpressed steps. Genes indicated in blue and green font represent endogenous and heterologous, respectively. Genes indicated in red font were endogenous gene knocked out. INO2, a transcription factor for lipid biosynthesis; ERG10, acetyl-CoA C-acetyltransferase; ERG13, hydroxymethylglutaryl-CoA synthase; tHMG1, truncated HMG-CoA reductase; ERG8, phosphomevalonate kinase; ERG12, mevalonate kinase; IDI1, isopentenyl diphosphate δ-isomerase; ERG20, farnesyl diphosphate synthase; ERG9, squalene synthase; ERG1, 2,3-oxidosqualene synthase; LPP1, phosphatidate phosphatase; PgDDS, dammarenediol-II synthase from Panax ginseng; PgPPDS protopanaxadiol synthase from Panax ginseng; AtCPR1, NADPH-cytochrome P450 reductase from Arabidopsis thaliana

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Microbial Cell Factories

ISSN: 1475-2859

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