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Fig. 10 | Microbial Cell Factories

Fig. 10

From: Oral or intranasal immunization with recombinant Lactobacillus plantarum displaying head domain of Swine Influenza A virus hemagglutinin protects mice from H1N1 virus

Fig. 10

Changes in body weight and survival rate of mice following a lethal challenge with influenza virus. Seven days after the last immunisation, all mice in the study group were intranasally challenged with H1N1 virus. a Body weight and c survival of mice orally immunised with PBS, pSIP401-ZN-3, or pSIP401-HA1-ZN-3 were monitored daily for 15 days following virus challenge; b Body weight and d survival of mice intranasally immunised with PBS, pSIP401-ZN-3, or pSIP401-HA1-ZN-3 were monitored daily for 14 days following virus challenge. Virus titres in (e) the lungs of mice orally immunised with PBS, pSIP401-ZN-3, and pSIP401-HA1-ZN-3 at DPC 6, and in (f) the lungs of mice orally immunised with PBS, pSIP401-ZN-3, and pSIP401-HA1-ZN-3 at DPC 6 are shown. Asterisks indicate statistically significant differences compared with the PBS-treated group (*p < 0.05, **p < 0.01, ***p < 0.001). PBS: phosphate-buffered saline

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Microbial Cell Factories

ISSN: 1475-2859

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