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Table 1 The role of AtsR, NCgl0887 and NCgl0884 in stress response

From: The TetR-type regulator AtsR is involved in multidrug response in Corynebacterium glutamicum

Compound

MIC

WT

(pXMJ19)

WT

(pXMJ19-atsR)

ΔatsR

(pXMJ19)

ΔatsR

(pXMJ19-atsR)

Δncgl0884

(pXMJ19)

Δncgl0884

(pXMJ19-ncgl0884)

Δncgl0887

(pXMJ19)

Δncgl0887

(pXMJ19-ncgl0887)

Δncgl0884 (pXMJ19-atsR)

Δncgl0887

(pXMJ19-atsR)

RIF(µg/ml)

0.00125

0.0025

0.00125

0.00125

0.0025

0.00125

0.00125

0.00125

0.005

0.00125

ERY (µg/ml)

1

0.125

1

1

0.125

1

1

1

0.125

1

SPE (µg/ml)

30

1.875

30

30

15

30

7.5

30

15

7.5

PEN (µg/ml)

350

43.75–87.5

350

350

87.5

350

43.75

350

87.5

43.75

NEO (µg/ml)

0.7

0.175

0.7

0.7

0.35

0.7

0.175

0.7

0.35

0.175

VAN (µg/l)

0.7

0.175

0.7

0.7

0.7

0.7

0.7

0.7

0.7

0.7

NOR (µg/ml)

1.25

0.078

1.25

1.25

0.625

1.25

0.3125

1.25

0.625

0.3125

STR (µg/ml)

1.25

0.156

1.25

1.25

1.25

1.25

0.3125

1.25

1.25

0.3125

GEN (µg/ml)

0.6

0.075

0.6

0.6

0.15

0.6

0.075

0.6

0.075

0.075

LIN (µg/ml)

9

1.125

9

9

1.5

9

1.5

9

1.55

1.5

H2O2 (mM)

110

13.75

100

110

27.5

110

55

110

27.5

55

Diamide (mM)

3

0.375

3

3

0.75

3

0.375

3

0.75

0.375

CDNB (µM)

7

7

7

7

7

7

7

7

7

7

IAM (µM)

300

150

300

300

300

300

300

300

300

300

EB (µM)

8

0.5–1

8

8

2

8

4

8

2

4

SDS (µg/ml)

200

50

200

200

200

200

50

200

50

50

CHP (mM)

0.69

0.1725

0.62

0.69

0.345

0.69

0.345

0.69

0.345

0.345

BZK (mM)

0.5

0.125–0.25

0.5

0.5

0.25

0.5

0.125

0.5

0.25

0.125

MEN (mM)

0.72

0.18–0.36

0.6

0.72

0.36

0.72

0.36

0.72

0.36

0.36

CdCl2 (µM)

60

30

60

60

30

60

60

60

30

60

CuCl2 (µM)

6

3

6

6

3

6

6

6

3

6

K2CrO7 (mM)

0.7

0.35

0.7

0.7

0.35

0.7

0.7

0.7

0.7

0.7

NiSO4 (mM)

2.5

0.625

2.5

2.5

0.625

2.5

2.5

2.5

2.5

2.5

  1. a MIC determination experiments were repeated at least three times. RIF, Rifampin; ERY, erythromycin; SPE, spectinomycin; PEN, penicillin; NEO, neomycin; VAN, vancomycin; NOR, norfloxacin; STR, streptomycin; GEN, gentamycin; LIN, lincomycin; H2O2, hydrogen peroxide; CHP, cumene hydrogen peroxide; CDNB, 1-chloro-2,4-dinitrobenzene; IAM, iodoacetamide; EB, ethidium bromide; SDS, sodium dodecyl sulfate; BZK, benzalkonium; MEN, menadione; CdCl2, cadmium chloride; CuCl2, copper chloride; K2CrO7, potassium dichromate; NiSO4, nickel sulfate
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Microbial Cell Factories

ISSN: 1475-2859

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