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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Metabolic engineering of Pichia pastoris for myo-inositol production by dynamic regulation of central metabolism

Fig. 1

Strategies for high-titer production of inositol in P. pastoris. Green arrows indicate the inositol biosynthesis pathway; orange arrows indicate glycerol catabolic pathway; genes in green indicate overexpression; genes in red indicate deletion or attenuation. G-3-P, glycerol-3-phosphate; DHAP, dihidroxyacetone-phosphate; G-6-P, glucose-6-phosphate; F-6-P, fructose-6-phosphate; F-1,6-BP, fructose-1,6-bisphosphate; I-3-P, inositol-3-phosphate; gut1, glycerol kinase; gut2, FAD-dependent glycerol-3-phosphate dehydrogenase; pgi, glucose-6-phosphate isomerase; pfk1, α-subunit of heterooctameric phosphofructokinase; pfk2, β-subunit of heterooctameric phosphofructokinase; IPS, inositol-3-phosphate synthase; IMP, inositol monophosphatase; zwf, glucose-6-phosphate dehydrogenase; PpITR1/PpITR2, inositol transporters

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Microbial Cell Factories

ISSN: 1475-2859

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