Fig. 7

Crystal structures of wild-type AGXT and mutants. a PLP binding residues in a single subunit. K209 is both a catalytic residue and one of the PLP-binding residues. The catalytic lysine and PLP-binding residues are shown as magenta sticks. b Polypeptide binding sites of a single subunit. The polypeptide binding residues are shown as cyan sticks. c Mutation sites in AGXT26. The 13 wild-type residues are marked on the left, and the corresponding mutant residues in AGXT26 are marked on the right. Wild-type residues were shown as blue sticks, the mutant residues are shown as red sticks; PLP (pyridoxal-5’-phosphate) is shown in yellow. The image was rendered using PyMOL. d Details of the mutation sites in AGXT26. ^a Synonymous mutation are underlined