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Fig. 3 | Microbial Cell Factories

Fig. 3

From: Speed dating for enzymes! Finding the perfect phosphopantetheinyl transferase partner for your polyketide synthase

Fig. 3

A A simplistic visualization of the two biosynthetic pathways of bikaverin and bostrycoidin, spanning the release from the ACP-domain to completed synthesis by the subsequent tailoring enzymes. B Multiple alignment of the three ACP-domains in Bik1 and Fsr1, alongside the template ACP-domain of NSAS used for structure prediction. The predicted α-helix structures are denoted on top of the alignment C 3D-structure of the ACP-domains native to Bik1 and Fsr1, showing the structural similarity of the four ACP-domains despite the sequence variation. The serine residue of the DxGxDSL motif where the phosphopantetheinyl arm is attached by the PPTase is highlighted

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