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Table 1 Summary of the bioactivities and biological targets for the described natural nucleoside antibiotics

From: Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments

Antibiotics

Producing strains

Bioactivities

Biological targets

BGC Accession no

Showdomycin

S. showdoensis ATCC 15227

Antibacterial

DNA and RNA polymerases

LAQS00000000a

Minimycin

S. hygroscopicus JCM 4712

Antibacterial, antitumor

RNA polymerase

MK122964

Formycin A

Noc. interforma ATCC 21072

S. kaniharaensis ATCC 21070

Antiviral, antibacterial

Adenosine kinase

KY682079

KY705052

MK830994

WBOF00000000b

Pyrazofurin A

S. candidus NRRL 3601

Antiviral, antitumor

OMP decarboxylase

MH493900

MN305320

Malayamycin A

S. malaysiensis DSM 14072

S. chromofuscus ATCC 49982

Antiviral, antifungal, anticancer

Unknown

KJ493330

MH537786

Pseudouridimycin

Streptomyces sp. ID38640

S. albus DSM 40763

Antibacterial

RNA polymerase

MG266907

RCIY01000000c

  1. aThe SDM BGC occupies an approximate 12.2-kb chromosomal region in S. showdoensis ATCC 15227
  2. bThe genome sequence of S. kaniharaensis ATCC 21070 is available in GenBank with the accession number WBOF00000000
  3. cThe PUM BGC from S. albus DSM 40763 is available with the accession RCIY00000000