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Fig. 2 | Microbial Cell Factories

Fig. 2

From: Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments

Fig. 2

Mechanism of C–C bond formation for related antibiotics. a The YeiC phosphorylates pseudouridine to produce PsiMP, and then hydrolyzed to uracil and ribose 5-P by YeiN. b β-RFAPS catalyzes the condensation of p-aminobenzoate (pABA) and PRPP to β-RFAP. c The pseudouridine is generated from isomerization of uridine-tRNA, catalyzed by TruD. YeiC, pseudouridine kinase; ribose 5-P, ribose-5′-Phosphate; β-RFAPS, β-RFAP synthase

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