Fig. 1
From: Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments
Chemical structures of C-nucleoside antibiotics featured in this review. a Structures of showdomycin (SDM), minimycin (MIN) and related compounds; this subgroup employs a YeiN-like strategy for C-glycosidic bond construction. b Structures of formycin A (FOR-A), pyrazofurin A (PRF-A) and structural analogs; for this subgroup, β-RFAP (β-ribofuranosyl-aminobenzene 5′-phosphate) synthase-like enzymes govern C-nucleoside scaffold construction in the biosynthesis of FOR-A and PRF-A. c Structures of tRNA, malayamycin A (MAL-A), and pseudouridimycin (PUM); the tRNA pseudouridylate synthases (TruD-like) are responsible for C-glycosidic bond formation in MAL-A and PUM biosynthesis