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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Production of 9,21-dihydroxy-20-methyl-pregna-4-en-3-one from phytosterols in Mycobacterium neoaurum by modifying multiple genes and improving the intracellular environment

Fig. 1

A schematic diagram of physterols side-chain degradation in Mycobacterium. ChoM, Cholesterol oxidase; CYP125, cytochrome P450 125; ChsEs, acyl-CoA dehydrogenases; ChsHs, 3-oxo-23,24-bisnorchol-4,17(20)-dien-22-oyl-CoA-hydratase; Ltp2, lipid transfer protein 2; Hsd4A, 17β-hydroxysteroid dehydrogenase/β-hydroxyacyl-CoA dehydrogenase; FadA5, acetyl-CoA acetyltransferase/thiolase; KstD, 3-ketosteroid-Δ1-dehydrogenase; KSH, 3-ketosteroid-9α-hydroxylase; 22-OH-24-CDOE-CoA, 22-hydroxy-3,24-dioxo-4-ene-cholest-CoA; 24-CTOE-CoA, 3,22,24-trioxo-4-ene-cholest-CoA; 22-PDOE-CoA, 3,22-dioxo-4-ene-pregna-CoA; 20-POECA, 3-oxo-4-ene-pregna-20-carboxylic acid; 20-POECAH, 3-oxo-4-ene-pregna-20-carboxyaldehyde

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Microbial Cell Factories

ISSN: 1475-2859

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