Fig. 2
From: The history, state of the art and future prospects for oleaginous yeast research
Simplified schematic description of the yeast fatty acid metabolism with a focus on de novo lipid formation. ACL ATP citrate lyase, MD malate dehydrogenase, ME malic enzyme; the enzymes catalyse reactions specific for oleaginous yeasts. *Pyruvate enters the mitochondria and undergoes oxidative decarboxylation to mitochondrial acetyl-CoA or is converted to cytosolic acetyl-CoA via the pyruvate–acetaldehyde–acetate pathway requiring ATP; **citrate is transported from the mitochondria into the cytosol and cleaved to cytosolic acetyl-CoA