Fig. 8

Efficacy of χ7122 pgl vaccine strains vectoring G-NetB(10) or unG-NetB against caecal colonisation by C. jejuni or lung colonisation by wt χ7122. a Experimental design; b, c Assessing reduction of C. jejuni 11168H colonisation of the caeca 1 week after challenge in b orally vaccinated chickens or c intra-air sac vaccinated chickens; d, e Assessing protection against homologous challenge with wt χ7122 in d orally vaccinated chickens or e intra-air sac vaccinated chickens. Colonisation levels of the caeca (for C. jejuni) and lungs (for wt χ7122) are expressed as log₁₀ CFU/g. Data are represented as median values with 95% confidence intervals. Statistically significant reductions are highlighted with * indicating p < 0.05 (GLM followed by Dunn’s post hoc). † indicates animals that were euthanised on presentation of end-point criteria specified in our licence for animal research