Fig. 1

Overview of biosynthetic pathway of L-valine in C.glutamicum, E. coli and B. subtilis. The solid red arrow shows the L-valine synthesis pathway and the solid blue arrow shows the inhibition pathway of L-valine synthesis. The red dotted line shows activation and the blue dotted line shows inhibition. a overview of biosynthetic pathway of L-valine in C.glutamicum; b overview of biosynthetic pathway of L-valine in E. coli; c overview of biosynthetic pathway of L-valine in B. subtilis. AHAS, acetohydroxyacid synthase; AHAIR, acetohydroxyacid isomeroreductase; DHAD, dihydroxyacid dehydratase; TA, transaminase B; AvtA, alanine transaminase; GPDH, glucose-6P dehydrogenase; PGL, 6-phosphogluconolactonase; PGDH, 6P-gluconate dehydrogenase; PGI, phosphoglucose isomerase; PFK, phosphofructokinase; Ldh, Lactate dehydrogenase; IlvA, L-threonine dehydratase; KHT, ketopantoate hydroxymethyltransferase; IPMS, 2-isopropylmalate synthase; LeuA, 2-isopropylmalate synthase; G-6-P, glucose 6-phosphate; F-6-P, fructose 6 phosphate; F16dP, Fructose 1,6 diphosphate; OXA, oxaloacetate; GL6P, gluconolactone 6-phosphate; 6PG, 6-phospho gluconate; Ru5P, ribulose 5-phosphate; EMP, Embden-Meyerhof-Parnas; TCA, tricarboxylic acid cycle; PPP, pentose phosphate pathway