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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Recombinant protein production provoked accumulation of ATP, fructose-1,6-bisphosphate and pyruvate in E. coli K12 strain TG1

Fig. 1

Growth inhibition in response to IPTG-induced production of hFGF-2 in batch culture. Time-course data of biomass, glucose, acetate and pyruvate concentrations and respiratory activity, volumetric carbon dioxide and oxygen transfer rates (A, B) during production of hFGF-2 with E. coli TG1:pJHLbFGF and (C, D) in the non-producing control culture with E. coli TG1:pJHLΔ growing under identical conditions. The insert in B depicts the time course of target protein production (total and soluble concentrations of hFGF-2 per biomass). The vertical lines indicate the time point of IPTG addition

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Microbial Cell Factories

ISSN: 1475-2859

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