Table 1 Outline of microbial polyketides that were heterologously produced in S. cerevisiae, including the type of reconstituted PKS, its origin and product titer

Anthracenone

TAN-1612 and derivatives

NRPKS, 1794 aa, 194.9 kDa,

SAT-KS-AT-PT-ACP

Fungal

8–10

[109]

Anthraquinone

Emodin

NRPKS, 1760 aa, 191.8 kDa,

SAT-KS-AT-PT-ACP

Fungal

592.5

[110]

Anthraquinone

Endocrocin

NRPKS, 1760 aa, 191.8 kDa,

SAT-KS-AT-PT-ACP

Fungal

134.5

[110]

Anthraquinone

DMAC

Type III, 404 aa, 44.6 kDa,

KS

Plant

Not reported

[111]

Benzoisochromane-quinone

Dihydrokalafungin

Type III, 404 aa, 44.6 kDa,

KS

Plant

Not reported

[111]

Benzochromenone

(nor)-rubrofusarin

NRPKS, 2067 aa, 225.1 kDa,

SAT-KS-AT-PT-ACP-TE

Fungal

0.2–1.1

[112]

Benzenediol lactone

Brefeldin A precursors

HRPKS, 2374 aa, 257.3 kDa,

KS-AT-DH-ER-KR-ACP

Fungal

0.5–4

[113]

Benzenediol lactone

Monocillin II and pochonin D

HRPKS, 2383 aa, 260.2 kDa,

KS-AT-DH-core-ER-KR-ACP

NRPKS, 2090 aa, 228.6 kDa,

SAT-KS-AT-PT-ACP-TE

Fungal

1.3–15

[114]

Benzenediol lactone

7',8'-dehydro-zearalenol

HRPKS, 2349 aa, 253.6 kDa,

KS-AT-DH-core-ER-KR-ACP

NRPKS, 2049 aa, 222.9 kDa,

SAT-KS-AT-PT-ACP-TE

Fungal

20

[115, 116]

Benzenediol lactone

10,11-dehydro-curvularin

HRPKS, 2389 aa, 260.6 kDa,

KS-AT-DH-MT*-KR*-ER-KR-ACP

NRPKS, 2079 aa, 227.7 kDa,

SAT-KS-AT-PT-ACP-TE

Fungal

11

[117]

Benzenediol lactone

trans-resorcylide, zearalane, lasicicol, 10,11-dehydro-curvularin, …

HRPKS, varied,

KS-AT-DH-ER-KR-ACP

NRPKS, varied,

SAT-KS-AT-PT-ACP-TE

Fungal

8–9

[114, 115, 118,119,120]

Benzenediol lactone

Monocillin II, 10,11-dehydrocurvularin, lasicicol, lasilarin, radilarin, radiplodin

HRPKS, varied,

KS-AT-DH-ER-KR-ACP

NRPKS, varied,

SAT-KS-AT-PT-ACP-TE

Fungal (combinatorial)

0.1–10

[118]

Benzo[b]xanthene

Bikaverin

NRPKS, 2036 aa, 221.5 kDa,

SAT-KS-AT-PT-ACP-TE/CLC

Fungal

0.7–41

[121]

Coumarin

Mellein

PRPKS, 1786 aa, 193.5 kDa,

KS-AT-DH-KR-ACP

Fungal

Not reported

[122]

Isocoumarin

de-O-methyldiaporthin

NRPKS, 2181 aa, 239.3 kDa,

SAT-KS-AT-ACP-ACP-TE/CLC*

Fungal

0.8–1.7

[93]

Furo[2,3-h]- isochromene

Chaetoviridin A and cazaldehyde precursor

HRPKS, 2383 aa, 257.2 kDa,

KS-AT-DH-MT-ER-KR-ACP

NRPKS 2746 aa, 298.9 kDa,

SAT-KS_AT-PT-MT-ACP-R

Fungal

0.5–1

[123,124,125]

Lactone

Triketide lactone

Type I, ~ 180 kDa,

KS-AT-KR-ACP-TE

Bacterial (combinatorial)

0.5–1

[75]

Phenol

3-ethyl- and 3-propyl-phenol

PRPKS, 1775 aa, 190.7 kDa,

KS-AT-DH-KR-ACP

Fungal

2.6–12.5

[86]

Phenolic acid

m-cresol

PRPKS, 1775 aa, 190.7 kDa,

KS-AT-DH-KR-ACP

Fungal

589

[126]

Phenolic acid

5-methyl-

orsellinic acid

NRPKS, 2590 aa, 283.7 kDa,

SAT-KS-AT-PT-ACP-ACP-MT-TE

Fungal

Not reported

[127]

Phenolic acid

6-methyl-

orsellinic acid

NRPKS, varied

SAT-KS-AT-DH-ACP-MT-RED or

SAT-KS-AT-DH-ACP-ACP-MT-EST

Fungal

0.5–1.7

[93]

Phenolic acid

6-methyl-

salicylic acid

PRPKS, 1775 aa, 190.7 kDa,

KS-AT-DH-KR-ACP

Fungal

200–2009

[80, 81, 87, 91, 126]

Phenolic acid

Orsellinic acid

NRPKS, 1728 aa, 190.2 kDa,

KS-AT-PT-ACP-TE

Fungal

1.8

[93]

Statin

Monacolin L and J acid

HRPKS, 3038 aa, 335.0 kDa,

KS-AT-DH-MT-ER*-KR-ACP-C

Fungal

20–75

[128,129,130]

Statin

Simvastatin

HRPKS, 3038 aa, 335.0 kDa,

KS-AT-DH-MT-ER*-KR-ACP-C

Fungal

55

(in vitro)

[128]