Design and heterologous expression of a novel dimeric LL37 variant in Pichia pastoris

Table 4 The MIC values (µM) of the peptides against E. coil ATCC 25922 in the presence of physiological salts

Peptide	Control^a	MIC under physiological salt concentration^b
Peptide	Control^a	NaCl	KCl	NH₄Cl	MgCl₂	CaCl₂	ZnCl₂	FeCl₃	GM	Fold
FR	8	> 32	8	8	32	> 32	8	16	19.50	2.44
rLG	2	2	2	2	4	> 32	2	2	3.62	1.81

^aThe control MIC values were determined in the absence of physiological salts and serum
^bThe final concentrations of NaCl, KCl, NH₄Cl, MgCl₂, CaCl₂, ZnCl₂, and FeCl₃ were 150 mM, 4.5 mM, 6 µM, 1 mM, 2 mM, 8 µM, and 4 µM, respectively

ISSN: 1475-2859