Design and heterologous expression of a novel dimeric LL37 variant in Pichia pastoris

Table 2 The MHC (µM), GM (µM) and SI values of the peptides

Peptide	MHC^a	GM^b	SI^c
(FR)₂	16	1.62	9.87
LG	64	2.00	32
LA	32	8.00	4

^aMHC is the concentration of peptide that causes 20% hemolysis as the minimum hemolysis concentration
^bGM is the geometric mean of the MIC value of the peptide against bacteria. When no antimicrobial activity is detected at 32 µM, use 64 µM to calculate the selectivity index
^cSelection index = MHC/GM, the larger the value, the higher the cell selectivity

ISSN: 1475-2859