Table 2 Effects of rhIL-2, rhIL-15 and IL-15/SuIL-15Rα-IgG4 Fc complexes on NK cell phenotypic markers
Marker | Ctrl | rhIL-2 | rhIL-15 | dFc | mFc |
|---|---|---|---|---|---|
CD69 | 5.8 ± 3.0 | 28.3 ± 13.9 | 81.4 ± 18.6 | 85.4 ± 11.8 | 78.6 ± 22.0 |
CD25 | 2.9 ± 0.6 | 3.5 ± 0.5 | 24.0 ± 8.6 | 24.6 ± 7.8 | 22.7 ± 8.2 |
CD94 | 65.6 ± 29.0 | 73.4 ± 22.2 | 86.2 ± 10.6 | 84.8 ± 12.1 | 85.2 ± 11.6 |
NKG2D | 75.6 ± 12.8 | 91.6 ± 5.4 | 96.1 ± 2.0 | 95.6 ± 2.7 | 95.7 ± 2.5 |
NKp44 | 2.3 ± 0.6 | 5.0 ± 1.5 | 9.2 ± 3.8 | 12.0 ± 3.6 | 8.9 ± 3.4 |
CD107a | 6.4 ± 2.1 | 11.2 ± 6.4 | 20.3 ± 9.7 | 21.7 ± 12.0 | 21.2 ± 7.9 |
IFN-γ | 1.4 ± 0.5 | 2.1 ± 0.7 | 10.0 ± 2.7 | 10.8 ± 2.1 | 11.7 ± 3.8 |
TRAIL | 20.0 ± 14.8 | 34.0 ± 13.4 | 60.1 ± 17.1 | 62.7 ± 15.4 | 60.8 ± 18.1 |
4-1BB | 2.3 ± 0.9 | 6.2 ± 3.6 | 15.3 ± 6.9 | 16.9 ± 7.8 | 15.0 ± 7.6 |
Granzyme B | 89.7 ± 4.4 | 96.3 ± 1.6 | 98.8 ± 0.8 | 98.9 ± 0.8 | 98.8 ± 0.9 |
Ki67 | 4.9 ± 1.7 | 7.3 ± 2.5 | 16.2 ± 2.6 | 16.6 ± 2.8 | 16.0 ± 2.2 |
Tim-3 | 9.0 ± 4.8 | 33.5 ± 11.7 | 57.1 ± 13.7 | 58.4 ± 15.4 | 55.4 ± 15.7 |
TIGIT | 29.3 ± 2.8 | 40.0 ± 5.9 | 55.4 ± 11.0 | 56.0 ± 7.9 | 55.7 ± 10.5 |