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Table 1 Function of mutations in IL-15/SuIL-15Rα-IgG4 Fc complexes

From: Development of IL-15/IL-15Rα sushi domain-IgG4 Fc complexes in Pichia pastoris with potent activities and prolonged half-lives

Mutation

Function

IL-15

 N71Q

Remove N-glycosylation modification

 N72D

Increase binding affinity to human IL-15Rβ, enhance biological activity of IL-15

 N79Q

Remove N-glycosylation modification

 N112Q

Remove N-glycosylation modification

IgG4 Fc

 L235E

Eliminate FcγR binding, reduce effector function

 S228P

Prevent Fab-arm exchange, stabilize the disulfides in the core hinge

 N297Q

Remove N-glycosylation modification