Mutation | Function |
---|---|
IL-15 | |
N71Q | Remove N-glycosylation modification |
N72D | Increase binding affinity to human IL-15Rβ, enhance biological activity of IL-15 |
N79Q | Remove N-glycosylation modification |
N112Q | Remove N-glycosylation modification |
IgG4 Fc | |
L235E | Eliminate FcγR binding, reduce effector function |
S228P | Prevent Fab-arm exchange, stabilize the disulfides in the core hinge |
N297Q | Remove N-glycosylation modification |