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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2

Fig. 1

Biosynthesis of the polyketide pamamycin in Streptomyces [11]. Succinyl-CoA displays the starter unit for biosynthesis. Malonyl-CoA, methylmalonyl-CoA, and ethylmalonyl-CoA represent alternative extender units, which lead to the different derivatives of the polyketide. The incorporation of the CoA thioesters results in the two hydroxy acids L and S, which are finally assembled to yield pamamycin

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