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Fig. 6 | Microbial Cell Factories

Fig. 6

From: Adaptive laboratory evolution accelerated glutarate production by Corynebacterium glutamicum

Fig. 6

Glutarate production by C. glutamicum GluA T0 (a) and GluA T7 (b) in bioreactors operated in batch mode. Both strains were cultivated in CGXII minimal medium in batch mode over 48 h, containing 40 g L−1 glucose. Glutarate production is indicated in green squares (g L−1), biomass concentration (CDW) is shown in black diamonds (g L−1), glucose concentration (g L−1) is plotted as pink hollow triangles, and 5AVA concentration (g L−1) in red diamonds and the relative dissolved oxygen saturation (rDOS) is indicated in light blue (%). Cultivation was performed at 30 °C and pH 7.0 regulated with 10% (v/v) H3PO4 and 4 M KOH. 0.6 mL L−1 of antifoam agent AF204 (Sigma Aldrich, Taufkirchen, Germany) was added to the medium manually before inoculation

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