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Fig. 6 | Microbial Cell Factories

Fig. 6

From: Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment

Fig. 6

A proposed simplified bioprocess flow diagram for an anti-SARS-CoV-2 monoclonal antibody production: 0. Inoculum train and culture media preparation. 1. Production bioreactor. 2. Cell harvesting (centrifugation or filtration). 3. Affinity (Protein-A) purification. 4. Low pH viral inactivation. 5. Ion exchange chromatography. 6. Virus removal. 7. Ultrafiltration / diafiltration and 8. Active Pharmaceutical Ingredient (API) formulation

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Microbial Cell Factories

ISSN: 1475-2859

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