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Table 2 Results of the biotransformation of 1-amino-1-(3-thienyl)methylphosphonic acid (1)

From: Phosphonates enantiomers receiving with fungal enzymatic systems

Biocatalyst

Cultivation medium

Time of cultivation (h)

Time of preincubation under starvation conditions (h)

Time of biotransformation (h)

e.e. a,b

[%]

R. mucilaginosa

PDB

72

0

72

35

72

24

72

28

YM

72

0

72

33

A. niger

PDB

96

0

24

31

96

24

24

52

96

0

72

27

96

24

72

89

MEP

96

0

72

6

F. oxysporum

PDB

96

0

72

14

96

24

72

35

MEP

96

0

72

42

96

24

72

30

M. circinelloides

PDB

96

0

72

31

96

24

72

49

A. parasiticus

PDB

96

0

72

< 5

96

24

72

12

  1. Bold values indicate best result
  2. aRacemic mixtures were enriched in (S)-enantiomer. bThe yield of bioconversion is adequate to the evaluated e.e. and in case of pure enantiomer synthesis the yield is 100%