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Table 1 Main enriched metabolic pathways of up-regulated genes

From: Enhanced ascomycin production in Streptomyces hygroscopicus var. ascomyceticus by employing polyhydroxybutyrate as an intracellular carbon reservoir and optimizing carbon addition

Gene no. KEGG ID Enzyme name Log2 (change fold)a P valuea
Starch and sucrose metabolism
 1_2422 SHJG_3718 alpha-glucosidase 3.0752 6.06 × 10–148
 1_2417 SHJG_3717 alpha-amylase 2.5774 1.81 × 10–16
 1_3621 SHJG_4827 trehalose-6-phosphate synthase 1.266 2.10 × 10–59
 1_6067 SHJG_7159 alpha-amylase 1.2268 4.07 × 10–07
 1_7923 SHJG_1896 beta-glucosidase 1.1619 6.11 × 10–06
ABC transporters
 1_1441 SHJG_3980 zinc transport system substrate-binding protein 4.3311 7.75 × 10–58
 1_2420 SHJG_3720 maltooligosaccharide transport system permease protein 4.2287 8.35 × 10–41
 1_1444 SHJG_3235 iron complex transport system ATP-binding protein 4.0095 1.55 × 10–29
 1_2421 SHJG_3721 maltooligosaccharide transport system substrate-binding protein 3.9837 0
 1_2419 SHJG_3719 maltooligosaccharide transport system permease protein 3.6265 5.76 × 10–32
 1_2743 SHJG_3235 iron complex transport system ATP-binding protein 2.9746 4.61 × 10–57
 1_2741 SHJG_3982 zinc transport system permease protein 2.9356 2.58 × 10–257
 1_2742 SHJG_8417 iron complex transport system ATP-binding protein 2.9089 1.10 × 10–83
 1_1279 SHJG_8416 iron complex transport system permease protein 1.8523 5.37 × 10–08
 1_1280 SHJG_8416 iron complex transport system permease protein 1.7734 8.39 × 10–07
 1_3705 SHJG_4851 multiple sugar transport system ATP-binding protein 1.518 6.19 × 10–29
 1_1281 SHJG_8418 iron complex transport system substrate-binding protein 1.4464 1.39 × 10–23
 1_4985 SHJG_3981 zinc transport system ATP-binding protein 1.0094 8.97 × 10–11
Ribosome
 1_1485 SHJG_6688 50S ribosomal protein L32 5.1594 7.62 × 10–181
 1_7134 SHJG_5164 30S ribosomal protein S18 3.8835 3.44 × 10–52
 1_7129 SHJG_7368 30S ribosomal protein S14 3.8384 1.82 × 10–14
 1_7130 SHJG_7369 50S ribosomal protein L28 3.7143 1.33 × 10–05
 1_2812 SHJG_4055 30S ribosomal protein S20 1.1893 9.08 × 10–12
 1_5742 SHJG_6711 30S ribosomal protein S16 1.0786 4.86 × 10–25
 1_6570 SHJG_3036 large subunit ribosomal protein L20 1.0423 1.61 × 10–10
 1_4696 SHJG_5834 30S ribosomal protein S9 1.0196 8.92 × 10–25
Pantothenate and CoA biosynthesis
 1_2437 SHJG_3745 3-methyl-2-oxobutanoate hydroxymethyltransferase 1.9693 5.22 × 10–56
 1_8015 SHJG_7832 L-aspartate-alpha-decarboxylase 1.7699 4.69 × 10–07
 1_3771 SHJG_5555 pantoate-beta-alanine ligase 1.6344 1.24 × 10–05
 1_3768 SHJG_5558 type III pantothenate kinase 1.4657 5.69 × 10–07
 1_5666 SHJG_6609 acetolactate synthase 1.1284 1.07 × 10–15
Nicotinate and nicotinamide metabolism
 1_7327 SHJG_8783 nicotinate phosphoribosyltransferase 2.8566 3.75 × 10–09
 1_3770 SHJG_5556 L-aspartate oxidase 1.7152 6.70 × 10–13
 1_7638 SHJG_2643 succinate-semialdehyde dehydrogenase 1.7112 3.27 × 10–233
 1_3769 SHJG_5557 nicotinate-nucleotide pyrophosphorylase 1.5887 9.02 × 10–06
 1_3164 SHJG_4395 nicotinamidase 1.1981 5.28 × 10–18
Sulfur metabolism
 1_1485 SHJG_6688 50S ribosomal protein L32 5.1594 7.62 × 10–181
 1_7134 SHJG_5164 30S ribosomal protein S18 3.8835 3.44 × 10–52
 1_7129 SHJG_7368 30S ribosomal protein S14 3.8384 1.82 × 10–14
 1_7130 SHJG_7369 50S ribosomal protein L28 3.7143 1.33 × 10–05
 1_2812 SHJG_4055 30S ribosomal protein S20 1.1893 9.08 × 10–12
 1_5742 SHJG_6711 30S ribosomal protein S16 1.0786 4.86 × 10–25
 1_6570 SHJG_3036 large subunit ribosomal protein L20 1.0423 1.61 × 10–10
 1_4696 SHJG_5834 30S ribosomal protein S9 1.0196 8.92 × 10–25
  1. aThe data was the comparative values between the strain FS35 and strain OphaCfkbU, with the strain FS35 as the control
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Microbial Cell Factories

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