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Fig. 7 | Microbial Cell Factories

Fig. 7

From: Expression of a recombinant FLT3 ligand and its emtansine conjugate as a therapeutic candidate against acute myeloid leukemia cells with FLT3 expression

Fig. 7

FL-DM1 selectively targets HCD-57 cells expressing FLT3. a Surface FLT3 expression levels in HCD-57 and HCD-57/FLT3-ITD cells. b The viability of HCD-57 and HCD-57/FLT3-ITD cells treated with 3 nM FL-DM1 or 3 nM DM1, *: p < 0.05. c Apoptosis of HCD-57 and HCD-57/FLT3-ITD cells treated with 3 nM FL-DM1. d FL-DM1 cytotoxicity on THP-1 cells under co-incubation with anti-FLT3 polyclonal antibody. FL-DM1: 20 nM, anti-FLT3 polyclonal antibody or isotype IgG: 10 µg/mL. **: p < 0.01

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Microbial Cell Factories

ISSN: 1475-2859

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