TY - JOUR AU - Zhou, Shaotong AU - Chen, Xiaotang AU - Ni, Xianpu AU - Liu, Yu AU - Zhang, Hui AU - Dong, Min AU - Xia, Huanzhang PY - 2021 DA - 2021/03/09 TI - Pyridoxal-5′-phosphate-dependent enzyme GenB3 Catalyzes C-3′,4′-dideoxygenation in gentamicin biosynthesis JO - Microbial Cell Factories SP - 65 VL - 20 IS - 1 AB - The C-3′,4′-dideoxygenation structure in gentamicin can prevent deactivation by aminoglycoside 3′-phosphotransferase (APH(3′)) in drug-resistant pathogens. However, the enzyme catalyzing the dideoxygenation step in the gentamicin biosynthesis pathway remains unknown. SN - 1475-2859 UR - https://doi.org/10.1186/s12934-021-01558-7 DO - 10.1186/s12934-021-01558-7 ID - Zhou2021 ER -