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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Fermentative production of enantiopure (S)-linalool using a metabolically engineered Pantoea ananatis

Fig. 1

Engineered (S)-linalool biosynthetic pathway in P. ananatis. Intermediates: DMAPP, dimethylallyl pyrophosphate; FPP, farnesyl pyrophosphate; GGPP, geranylgeranyl pyrophosphate; GPP, geranyl pyrophosphate; HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A; IPP, isopentenyl pyrophosphate. Genes and enzymes: AaLINS, (S)-linalool synthase; CrtE, GGPP synthase; IDI, IPP isomerase; IspA*, GPP synthase; GCD, membrane-bound glucose dehydrogenase; MvaE, acetoacetyl-CoA thiolase and HMG-CoA reductase; MvaS, HMG-CoA synthase; MVD, mevalonate pyrophosphate decarboxylase; MVK, mevalonate kinase; PhoB, phosphate regulon transcriptional regulatory protein; PhoR, phosphate regulon sensor protein; PMK, phosphomevalonate kinase

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