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Table 1 Predictions of “hot spots (HS)” of aggregation in aggregating polypeptides by AGGRESCAN [8]

From: Title: insoluble proteins catch heterologous soluble proteins into inclusion bodies by intermolecular interaction of aggregating peptides

Name

HS region

HS size

Sequence

HSA

NHSA

a4vAHS

Ref.

L6K2

1–6

6

LLLLLLKK

6.211

1.035

0.949

[22]

(L6K2)x2

1–14

14

LLLLLLKKLLLLLLKK

12.789

0.913

0.865

This study

(L6K2)x3

1–22

22

LLLLLLKKLLLLLLKKLLLLLLKK

19.367

0.880

0.842

This study

L12K4

1–13

13

LLLLLLLLLLLLKKKK

14.625

1.125

1.074

This study

L18K6

1–19

19

LLLLLLLLLLLLLLLLLLKKKKKK

23.025

1.212

1.171

This study

  1. HS hot spot, HSA hot spot area, NHSA normalized HSA, a4vAHS average aggregation-propensity in each HS