Fig. 3From: Comparative genomics and transcriptomics analyses provide insights into the high yield and regulatory mechanism of Norvancomycin biosynthesis in Amycolatopsis orientalis NCPC 2-48Metabolic pathway of norvancomycin biosynthesis up-regulated in high-yield strain. Three steps are involved in the biosynthesis of norvancomycin: I) the biosynthesis of amino acid precursors, II) The modified amino acids are assembled to form linear heptapeptide by NRPSs, III) The post-modifications of the linear heptapeptide. Red box at each gene indicates that its transcriptional level was up-regulated (> two-fold change and FDR ≤ 0.001) in NCPC 2–48 at 24 hBack to article page