Multi-pathogen infections and Alzheimer’s disease

Table 3 Antimicrobial agents that have been used to treat patients with AD

Authors, Years	Agents	Participants	Study design	Outcome	References
Tzeng et al., 2018	Acyclovir, Famciclovir, Gangciclovir, Valacyclovir, Valganciclovir	8362	Cohort study	Decreased risk of dementia	[77]
Devanand et al., 2020	Valacyclovir	130	Randomized, double-blind, controlled trial	NA	[81]
Loeb et al., 2004	Rimfapicin, Doxycycline	101	Randomized, triple-blind, controlled trial	Lower cognitive decline	[83]
Kountouras et al., 2009	Amoxicillin, Clarithromycin	56	Cohort study	Cognitive function improvement	[89]
Howard et al., 2020	Minocycline	554	Randomized, double-blind, controlled trial	No effect on cognitive function	[94]
Dominy et al., 2019	COR388	573	Randomized, double-blind, controlled trial	NA	[95]

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