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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Metabolic engineering Saccharomyces cerevisiae for de novo production of the sesquiterpenoid (+)-nootkatone

Fig. 1

Scheme of (+)-nootkatone biosynthesis based on the MVA pathway in S. cerevisiae. To increase the metabolic flux of the MVA pathway in S. cerevisiae, tHMG1 was overexpressed and the competitive ERG9 pathway was dynamically controlled by replacing its endogenous promoter with PHXT1. ERG20 was simultaneously fused with CnVS of C. nootkatensis and overexpressed to channel the metabolic flux to (+)-valencene production. The production of (+)-nootkatone was achieved by the overexpression of HPO, ATR1, and the indicated dehydrogenases

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