Skip to main content
Fig. 1 | Microbial Cell Factories

Fig. 1

From: Surface components and metabolites of probiotics for regulation of intestinal epithelial barrier

Fig. 1

Structure, function, and probiotics of intestinal epithelial barrier. The mucus secreted by goblet cells continuously replenishes the mucosal layer that covers the intestinal epithelium, which acts as the first physical barrier against pathogenic bacteria. The symbiotic bacteria in the outer mucus layer can ferment dietary fiber into SCFAs, providing important energy sources for colonic intestinal cells and goblet cells. Paneth cells secrete a variety of antibacterial substances, such as antimicrobial peptides and Reg3γ. These antibacterial substances and secretory IgA are secreted into mucus to protect against commensal pathogens. The microorganism-associated molecular patterns (MAMPs) of probiotics can be recognized by PRRs such as TLRs, which induces the response of dendritic cells (DCs) to provide the protection on gut epithelial barrier. PRRs pattern recognition receptors, SCFAs short-chain fatty acids

Back to article page