Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-batch cultivations through morphological and physiological control

Table 3 Summary of fit for model responses

Model response	Model parameter (95% significance level)	R2	Q2	Model validity	Reproducibility
Pellet size	P/V	0.60	0.43	0.50	0.93
Pellet compactness	P/V	0.58	0.45	–	0.99
Viable pellet layer	q_s, P/V, dO₂	0.78	0.58	0.88	0.71
Mean specific productivity	q_s	0.71	0.48	0.58	0.91

Ranges to differentiate good models according to MODDE: R2 (> 0.5), Q2 (> 0.1 for a significant model, > 0.5 for good model), Model validity (> 0.25), Reproducibility (> 0.5)

ISSN: 1475-2859