Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-batch cultivations through morphological and physiological control

Table 1 Multivariate experimental design of 11 + 3 bioreactor cultivations, nomenclature and factors with mean values over process time including standard deviation

Name	P/V [W/m³]	Q_s [g_s/g_x/h]	dO₂ [%]
LLL	0370 ± 10	0.017 ± 0.003	5.0 ± 1.5
HLL	2012 ± 20	0.018 ± 0.001	5.0 ± 1.6
LHL	0370 ± 12	0.040 ± 0.012	5.0 ± 3.1
HHH1	1900 ± 15	0.042 ± 0.004	40.0 ± 6.5
LLH	0370 ± 11	0.015 ± 0.004	40.0 ± 5.2
MMH	1535 ± 20	0.038 ± 0.003	40.0 ± 4.1
LHH	0370 ± 14	0.045 ± 0.004	40.0 ± 5.2
HHH2	2700 ± 15	0.049 ± 0.005	40.0 ± 7.5
CP1	1535 ± 11	0.034 ± 0.005	22.5 ± 6.6
CP2	1535 ± 11	0.033 ± 0.005	22.5 ± 5.0
CP3	1535 ± 12	0.035 ± 0.003	22.5 ± 6.9
MHH	1113 ± 14	0.054 ± 0.005	40.0 ± 5.4
CP4	1535 ± 32	0.026 ± 0.003	22.5 ± 3.9
HHH3	3000 ± 34	0.050 ± 0.005	40.0 ± 9.5

ISSN: 1475-2859