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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol

Fig. 1

Proposed celastrol biosynthetic pathway. Dashed arrows depict multiple enzymatic steps. Friedelin synthase (FRS) performs the first committed step of the pathway by cyclization of the common triterpenoid precursor 2,3-oxidosqualene into friedelin. Next, CYP712K1, CYP712K2 or CYP712K3 catalyzes successive oxygenations of friedelin to form polpunonic acid (6) via 29-hydroxy-friedelin (5) and 29-oxo-friedelin (10). Enzymes of different types are proposed to perform the rest of the reactions to obtain celastrol

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Microbial Cell Factories

ISSN: 1475-2859

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