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Table 1 List of partial differential expression proteins identified by the iTRAQ analysis

From: Effects of ccpA gene deficiency in Lactobacillus delbrueckii subsp. bulgaricus under aerobic conditions as assessed by proteomic analysis

Accession

Protein description

MW [kDa]

Coverage

Fold change

T/Ca

Cellular response to stimulus

 F0HVQ0

SOS regulatory protein LexA

22.16

2.91

2.228

 A0A061BVN8

Regulatory protein RecX

30.45

3.32

2.106

 S2KUP9

Transcriptional regulator

34.81

1.92

1.872

 A0A061BU68

Transcriptional regulator (Crp family)

35.63

3.43

1.714

 A0A061CJZ0

Transcriptional regulator (MarR family)

13.13

17.39

1.636

 A0A061CK68

Heat-inducible transcription repressor HrcA

39.09

4.03

1.602

 A0A061BU38

DNA repair protein RecO

27.59

6.83

1.524

 Q1G937

GroEL chaperonin

57.30

78.77

− 1.592

 A0A061CKD6

Chaperone protein DnaK

66.02

64.50

− 1.600

 A0A061C1K9

Response regulator

27.86

55.60

− 1.715

 Q048Y2

GroES chaperonin

10.27

85.11

− 1.802

 A0A061BLC4

Heat-shock protein Hsp20

15.79

56.03

− 2.288

 G8I2M0

Translation elongation factor Tu

9.71

34.44

− 2.985

Carbohydrate transport and metabolism

 A0A061BX52

EpsIIH, glycosyltransferase

42.16

18.01

1.802

 Q1G8F3

EpsIM, glycosyltransferase

40.55

24.17

1.744

 Q1G8E9

EpsIH, glycosyltransferase

31.48

28.09

1.624

 Q1G7Z6

Pyruvate oxidase

67.67

64.94

1.592

 Q1G8E8

EpsIG, glycosyltransferase

19.19

38.92

1.529

 Q1GAY6

Acetate kinase

43.16

46.08

1.512

 Q71HT0

Phosphopyruvate hydratase

15.15

82.19

− 1.520

 A0A061BLT3

Galactosyltransferase

39.99

9.02

− 1.567

 A0A061CQG7

Phosphoglycerate kinase

42.71

80.89

− 1.678

 D8FNY3

Pyruvate kinase

62.90

53.99

− 1.949

 A0A061BZB8

6-Phosphofructokinase

38.76

54.87

− 2.268

 D8FN74

d-lactate dehydrogenase

36.98

56.46

− 2.283

 D8FM36

Ribose-phosphate diphosphokinase

36.91

42.22

− 3.636

Lipid transport and metabolism

 A0A061BKY2

Acyl-phosphatelycerol 3-phosphate acyltransferase

29.91

2.33

1.579

 A0A061BRJ8

Glycerophosphoryl diester phosphodiesterase

26.73

16.96

1.500

 Q1G9C4

Putative acylphosphatase

10.05

46.67

− 1.522

 A0A061C1U5

Geranylgeranyl pyrophosphate synthase

32.95

35.14

− 1.667

 G6EWT6

Cyclopropane-fatty-acyl-phospholipid synthase

44.22

44.16

− 2.247

Amino acid transport and metabolism

 A0A061BW11

Cysteine–tRNA ligase

53.65

37.97

− 1.534

 D8FQC5

Arginine–tRNA ligase

64.10

58.05

− 1.610

 A0A061BMI1

Homoserine O-succinyltransferase

29.79

13.85

− 1.618

 Q1GBX1

Amino acid ABC transporter, substrate binding protein

31.98

55.59

− 1.626

 Q04CP9

S-ribosylhomocysteine lyase 1

17.85

68.55

− 1.672

 A0A061BL94

Amino acid ABC transporter, ATP-binding protein

28.25

52.44

− 1.818

 A0A061BUC1

Cystathionine gamma-synthase

43.06

44.67

− 1.832

 G6EWC8

Serine protease

43.42

3.53

− 1.873

 Q1G9F7

Phosphoribosylformylglycinamidine synthase subunit PurQ

24.22

11.61

− 2.165

 A0A061BUK8

Cysteine synthase

32.43

58.31

− 2.174

 A0A0D6ZH63

Amino acid ABC transporter permease

25.34

12.95

− 2.252

Genetic information processing

 Q1GBK0

50S ribosomal protein L30

6.67

60.66

3.435

 Q04BZ9

50S ribosomal protein L18

12.92

73.95

2.171

 Q71J17

50S ribosomal protein L22

10.58

68.37

2.147

 G6F488

Ribosome maturation factor RimP

15.52

11.28

1.949

 D8FNZ8

RNA polymerase sigma factor

42.76

30.42

1.760

 Q049M4

50S ribosomal protein L21

11.33

61.17

1.693

 Q1GBK4

30S ribosomal protein S8

14.44

70.45

1.689

 A0A061CI05

30S ribosomal protein S14

7.09

11.48

1.687

 Q1G904

50S ribosomal protein L10

18.18

70.41

1.647

 Q1GBL8

50S ribosomal protein L3

22.75

73.68

1.598

 Q1GBI6

50S ribosomal protein L13

16.38

73.47

1.581

 F0HX40

50S ribosomal protein L24

8.21

58.23

1.572

 F0JZX6

30S ribosomal protein S17

10.49

45.45

1.542

 G6EVN1

50S ribosomal protein L4

21.87

43.72

1.529

 Q04BZ2

50S ribosomal protein L36

4.41

26.32

1.517

 Q1G7Z4

tRNA modification GTPase MnmE

49.93

32.32

1.510

 Q1G905

50S ribosomal protein L12

12.34

59.50

1.506

 F0HW20

50S ribosomal protein L34

5.41

13.04

− 1.529

 Q1G8Z5

50S ribosomal protein L33

5.49

20.41

− 2.141

Nucleotide metabolism

 A0A061BND

Cytidine deaminase

15.43

4.32

2.065

 Q1GA92

Pseudouridine synthase

33.87

11.22

1.955

 G6F8G6

N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase

15.54

12.12

1.676

 F0JZF8

Inosine-5′-monophosphate dehydrogenase

40.13

79.74

− 1.534

 A0A061C7C2

Putative pyridine nucleotide-disulphide oxidoreductase

48.70

59.69

− 1.560

Other metabolism

 A0A0D6ZHP8

Glutamine transporter, ATP-binding protein

27.16

10.16

1.714

 F0HUZ5

FeS cluster assembly scaffold IscU

15.81

18.49

1.691

 Q1G9D0

membrane protein

93.97

1.68

1.635

 A0A061BP48

Thioredoxin

12.00

79.25

1.542

 Q1GAT1

Cell division protein SepF

15.63

62.32

1.534

 Q1GAK5

Segregation and condensation protein B

22.21

39.00

1.528

 A0A061BY60

Hydrolase (NUDIX family)

19.83

8.62

− 1.513

 A0A061BWU4

ABC transporter, ATP-binding protein

23.77

53.30

− 1.572

 Q1G869

ATP-dependent Clp protease, ATP-binding subunit clpL

76.90

76.87

− 1.600

 D8FM00

Phosphonate ABC transporter, substrate-binding protein

34.08

46.33

− 1.603

 D8FPT9

ATP-dependent Clp protease, ATP-binding subunit clpE

76.96

61.78

− 1.637

 G6EW12

Peptide hydrolase

51.31

31.28

− 1.650

 A0A061BU80

Cation transporting P-type ATPase

81.71

29.80

− 1.653

 A0A061BUM1

Phosphoribosylglycinamide formyltransferase

21.64

10.88

− 1.658

 A0A061BVN4

2,5-didehydrogluconate reductase

31.01

26.09

− 1.678

 A0A061CDM4

X-Pro dipeptidase PepQ

41.09

48.10

− 1.783

 D8FLL0

ATP synthase subunit beta

52.10

60.33

− 1.832

 Q71IA3

3-Hydroxy-3-methylglutaryl-coenzyme A reductase

15.95

24.16

− 1.852

 A0A061CI27

ATP-dependent Clp protease, ATP-binding subunit clpC

90.83

48.60

− 2.169

  1. aAverage fold-change was calculated as the ratio of the CcpA-negative mutant of L. bulgaricus ATCC11842 to the parental strain for up-regulated proteins and as the negative reciprocal values for down-regulated proteins, Proteins with the fold-change of ≥ 1.5 or ≤ − 1.5 and P-value < 0.05 were considered to be significantly up-regulated or down-regulated, respectively, based on statistic analysis for three biological replicates [19]