Table 1 Secondary metabolite gene clusters deleted within the chromosome of S. lividans TK24 and resulting strains
Cluster | Product | Coordinates of deleted genes | Size of the gene cluster (kb) | Size of deleted region (Kb) | Strain ID |
|---|---|---|---|---|---|
Cluster 10 | Undecylprodigiosin | 09100–09185 | ≈ 47.65 | ≈ 26.5 | ΔYA1 |
Cluster 14 | Actinorhodin | 12,885–12965 | ≈ 41.55 | ≈ 15.3 | ΔYA2 |
Cluster 17 | Melanin | 24135–24185 | ≈ 9.17 | ≈ 8 | ΔYA3 |
Cluster 13 | Terpene | 12220–12265 | ≈ 21.67 | ≈ 11.7 | ΔYA4 |
Cluster 19 | Germicidin | 31668–31860 | ≈ 42.26 | ≈ 40 | ΔYA5 |
Cluster 15 | CDA | 21535–21540 | ≈ 80.87 | ≈ 27 | ΔYA6 |
Cluster 6 | Coelimycin | 06755–06775 | ≈ 79.56 | ≈ 20 | ΔYA7 |
Cluster 2 | Coelibactin | 00885–00925 | ≈ 73.28 | ≈ 17 | ΔYA8 |
Cluster 24 | Eicosapentaenoic acid | 37285–37305 | ≈ 53.55 | ≈ 13 | ΔYA9 |
Cluster 21 | Coelichelin | 35395–35490 | ≈ 51.22 | ≈ 32::attB2 | ΔYA10 |
Cluster 5 | NRPS | 06215–06270 | ≈ 48.64 | ≈ 18::attB3 | ΔYA11 |