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Table 1 Proposed function of gene homologues identified in the CHD BGC

From: Heterologous expression of the atypical tetracycline chelocardin reveals the full set of genes required for its biosynthesis

Gene

Size (AA)

Putative function

Protein homologue (GenBank Accession Number)

Identity/similarity (%)

chdP

432

Ketosynthase alpha

OxyA (P43678.2)

78/85

chdK

418

Ketosynthase beta

OxyB (AAZ78326.1)

71/82

chdS

88

Acyl carrier protein

OxyC (P43677.1)

62/77

chdQI

302

Aromatase/cyclase

OxyK (AAZ78334.2)

32/48

chdMII

343

Methyltransferase

CmmMII (CAE17532.1)

45/61

chdGIV

399

Glycosyltransferase

CmmGIV (CAE17547.1)

39/51

chdTn

511

Transposase

InsG (P03835.1)

25/40

chdR

481

Exporter

EmrB (P9WG88.1)

33/54

chdA

190

Transcriptional regulator

TetR (5MRU_A)

43/56

chdN

448

Aminotransferase

Msat (1WST_A)

31/47

chdOI

404

Oxygenase

OxyE (AAZ78329.1)

66/78

chdMI

341

Methyltransferase

OxyF (AAZ78330.1)

66/76

chdL-chdOIII

643

Acyl-CoA ligase/oxygenase

OxyH (ELQ83297.1)

56/69

chdOIII

96

Oxygenase

OxyG (AAZ78331.1)

63/76

chdX

150

Cyclase

OxyI (AAZ78332.2)

64/74

chdT

262

Ketoreductase

OxyJ (AAZ78333.1)

76/85

chdQII

315

Aromatase/cyclase

OxyK (AAZ78334.2)

58/67

chdOII-chdY

806

Oxygenase/cyclase

OxyL (AAZ78335.1)

59/69

chdY

256

Cyclase

OxyN (AAZ78337.1)

73/80

chdB

258

Transcriptional activator (SARP family)

OtcR (AJO26937.1)

45/63

chdC

212

Transcriptional activator (LuxR family)

OtcG (ACM67367.1)

35/56