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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Engineering the Calvin–Benson–Bassham cycle and hydrogen utilization pathway of Ralstonia eutropha for improved autotrophic growth and polyhydroxybutyrate production

Fig. 1

Overview of the autotrophic metabolic pathways and engineering strategy of a R. eutropha H16 microbial cell factory to improve autotrophic growth and PHB production. The autotrophic metabolism of R. eutropha H16 is based on the CBB cycle and hydrogenases for energy supply. The red arrows indicate focuses of the engineering strategy. PhaA: β-ketothiolase; PhaB: NADPH-dependent acetoacetyl-CoA reductase; phaC: PHB synthase; MBH: membrane-bound hydrogenase; SH: soluble hydrogenase; RH: regulatory hydrogenase; Hyd4: NiFe hydrogenase

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Microbial Cell Factories

ISSN: 1475-2859

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