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Table 1 Previous attempts to optimize the medium or genetic background of Synechocystis sp. PCC 6803 for the production of PHB. Further approaches (also in other cyanobacteria) have been reviewed recently [19]

From: Maximizing PHB content in Synechocystis sp. PCC 6803: a new metabolic engineering strategy based on the regulator PirC

Genotype PHB content (% CW) substrate Production condition Polymer composition References
WT 29 0.4% acetate –P PHB [38]
overexpression phaAB (native) 35 0.4% acetate –N PHB [21, 22]
overexpression phaABC (Cupriavidus necator) 11 10 mM acetate –N PHB [42]
overexpression nphT7, phaB, phaC 41 0.4% acetate Limited air exchange, –N [28]
overexpression Xfpk 12 CO2 –N, –P PHB [5]
overexpression sigE 1.4 CO2 –N PHB [36]
overexpression rre37 1.2 CO2 –N PHB [37]