Gut microbiome as a response marker for pancreatic enzyme replacement therapy in a porcine model of exocrine pancreas insufficiency

Table 2 Increased abundance in percent of bacterial genera in pancreatic duct-ligated Göttingen minipigs compared to PERT treated animals

Increased bacterial genera	EPI		EPI + PERT		Δ	p	p_cor
Increased bacterial genera	Med.	IQR	Med.	IQR	Δ	p	p_cor
Sphingomonas	0	0	0	0.042	443.03	0.009	0.082
Streptococcus	0.106	0.145	0.335	0.536	149.42	0.043	0.249
Mogibacterium	0	0	0.038	0.045		0.009	0.078
Pseudobutyrivibrio	0	0	0.049	0.084		0.009	0.075
Clostridium_XI	0.271	0.254	0.639	0.374	73.89	0.033	0.223

Bacterial genera with a noteworthy increased abundance after 28 days of PERT according to the Wilcoxon signed-rank test (α = 0.05) are listed
EPI: relative abundance in EPI affected pigs; EPI + PERT: relative abundance in EPI pigs after treatment; med.: median; IQR: interquartile range; Δ: relative change based on original mean abundance; p: p-value; p_cor: p-values corrected according Benjamini–Hochberg method
All values are in percent and genera are shown in taxonomic order

ISSN: 1475-2859